Multiple Myeloma
CandidateCan | DiscoveryDisc | PreclinicalPre | Phase 1P1 | Phase 2P2 | Phase 3P3 |
---|---|---|---|---|---|
CART-ddBCMA | ![]() CART-ddBCMA is a cell therapy candidate involving patient-derived, or autologous, T cells that have been genetically modified to recognize and kill specific cells expressing BCMA, a target antigen for multiple myeloma. This candidate utilizes a chimeric transmembrane protein for antigen recognition that includes a novel proprietary binding domain in place of the traditional scFv binding domain of conventional cell therapies. The domain has been engineered to reduce immunogenicity. Arcellx’s CART-ddBCMA Phase 1 trial for the treatment of relapsed and refractory multiple myeloma has been granted Fast Track and Orphan Drug designations by the U.S. Food and Drug Administration. | ||||
ACLX-001 | ![]() ACLX-001 is in development for the treatment of multiple myeloma. ACLX-001 is composed of ARC-T cells and a bivalent sparX protein targeting BCMA. This sparX-BCMA protein utilizes the same antigen binding domain as the Arcellx CART-ddBCMA. | ||||
Discovery | ![]() Arcellx is exploring additional targets for the treatment of MM. |